A Spanish plane with more than 170 people on board went off the runway Wednesday at Madrid's Barajas Airport, killing at least 90 people, officials said. The crash during take off reportedly followed an explosion on board the budget airline jet, sending up a plume of smoke visible from miles away.

The official death toll is 90, according to Interior Ministry officials. But local officials are telling CNN's Spanish sister station CNN+ that 26 people taken to hospital are the only survivors.

Some of those survivors have serious injuries and others non-life threatening injuries, Spanish Red Cross spokeswoman Olivia Acosa told CNN. Many of the injured were treated for burns, she said.

The incident happened as Spanair Flight 5022 was taking off from the main runway, the official said. It was headed to Las Palmas in the Canary Islands, a more than two-hour flight.