Researchers from the University of California published a study last week in the New England Journal of Medicine that appears to put a damper on the long-held belief that today's most popular antidepressant medications are really safe in pregnancy. Selective Serotonin Reuptake Inhibitors (SSRIs) are the mainstay of today's medical therapy for depression, because they usually work, and their safety and side-effect profiles are attractive. This class of medications includes the popular brand-names Prozac, Zoloft, Paxil, Celexa and Lexapro.